
A new study shows that the long-term use of either cannabis or cannabis-based drugs impairs memory. The study, published in the Journal of Neurochemistry, reveals the implications for both recreational users and people who use the drug to combat epilepsy, multiple sclerosis and chronic pain.
Through the legalisation in several countries of cannabis or cannabis-based drugs, there is an increased number of long-term users and more potent varieties are available for recreational users. It is already known that heavy, regular cannabis use increases the risk of developing mental health problems including psychosis and schizophrenia. However, there is still little understanding of the potential negative side effects of long-term cannabinoid exposure.
Now, the research group led by Ana Sebastião, group leader at Instituto de Medicina Molecular João Lobo Antunes and Professor of Faculdade de Medicina of Universidade de Lisboa (iMM, FMUL; Portugal) and her team in collaboration with researchers from the University of Lancaster (UK), studied the effects of a specific cannabinoid drug (named WIN 55,212-2) and found that mice exposed for long-term to the drug had “significant memory impairments” and could not even discriminate between a familiar and novel object. Also, brain imaging studies showed that the drug impairs function in key brain regions involved in learning and memory. Moreover, the long-term exposure to the drug impairs the ability of brain regions involved in learning and memory to communicate with each other, suggesting that this underlies the negative effects of the drug on memory.
“Importantly, our work clearly shows that prolonged cannabinoid intake, when not used for medical reasons, does have a negative impact in brain function and memory. It is important to understand that the same medicine may re-establish an equilibrium under certain diseased conditions, such as in epilepsy or multiple sclerosis, but could cause marked imbalances in healthy individuals. As for all medicines, cannabinoid-based therapies have not only beneficial disease-related actions, but also negative side effects,” says Ana Sebastião. A previous study from the same team has showed that acute exposure to cannabinoids results in recognition memory deficits, an effect that can be prevented by the use of a drug of the family of caffeine. “These results are very important for the development of pharmacological strategies aiming to decrease cognitive side effects of currently used cannabinoid-based therapies, which proved effective against several nervous system disorders,” explains Ana Sebastião.
“This work offers valuable new insight into the way in which long-term cannabinoid exposure negatively impacts on the brain. Understanding these mechanisms is central to understanding how long-term cannabinoid exposure increases the risk of developing mental health issues and memory problems; only its understanding will allow to mitigate them,” says Neil Dawson.
.
© Edublox
Reading and learning made easy –
Video: It’s life-changing! Edublox helps overcome learning challenges
Watch Naeleigh’s heart-warming story of overcoming learning challenges. While Edublox’s Development Tutor is improving her cognitive skills like concentration, processing, memory and reasoning, Live Tutor and additional homework exercises provided by Edublox address her reading, spelling and math deficits. Continue Reading
Ashlyn, mom of Naeleigh, US Edublox Online Tutor May 26, 2022
Video: Overcoming reading difficulties — Four children testify
Four children, Kelsey, Tshepo, Liam and Joshua share how struggling to read affected them, as well as how it feels now that they can read. Contact Edublox for help if your child struggles with similar problems.
Continue ReadingKelsey, Tshepo, Liam and Joshua Edublox Online Tutor March 5, 2022
Overcoming dyslexia: Elize tells her family’s experience
Elize tells her family's experience with Edublox. When her youngest daughter (now 25 years old) was in 4th grade, she realized her reading was not on par. The school said she should not worry. Continue Reading
Elize, mom of Marie-Louise Edublox Online Tutor March 5, 2022
Dyslexia & dyscalculia diary and video: “We can see her world getting bigger”
The whole Edublox system has helped Amy so much with reading and math, but it was hard for us to tell if it was helping her with this hidden, agonizing challenge. It certainly is! Continue Reading
Sandy, mom of Amy, US Edublox Online Tutor January 5, 2022
Video: Edublox’s online tutoring delivers demonstrable results
Dennis shares how Edublox is teaching his daughter Veronica to read after other programs had failed. She was diagnosed with apraxia. Apraxia is a neurological condition that makes certain motor movements difficult. It may affect speech and coordination, and may co-occur with learning disorders such as dyslexia and dyscalculia. Continue Reading
Dennis, Veronica's dad, US Edublox Online Tutor October 29, 2021
Dyseidetic dyslexia video: Measurable improvements in reading scores
Hilary shares her thoughts on "The Edublox Experience." Measurable improvements in standardized reading scores, confidence and fun. Continue Reading
Hilary, Rief's mom, US Edublox Online Tutor October 11, 2021
Video: Overcoming dyslexia and developmental delays
Vivienne was adopted from China at age 5. This video is about Susan helping her 11-year-old daughter overcome developmental delays, including dyslexia. They started with the Edublox program 13 weeks ago. This is their story. Continue Reading
Susan, Vivienne's mom, US Edublox Online Tutor August 22, 2021
“Carsten is reading 6 and 7 letter words and the most amazing part is he is spelling them as well!”
Now, after working with Susan and the Edublox program for the last 5 months, Carsten is reading 6 and 7 letter words and the most amazing part is he is spelling them as well! AMAZING! I never would have thought he would be spelling words that large so quickly. I asked his school teacher about what she has seen and she told me she’s seen a big difference... Continue Reading
Lisel Nielsen, Utah, US Edublox Online Tutor March 12, 2020
Video: Student with severe dyslexia improves from the 1st to the 55th percentile!
Meet Maddie, a 10-year-old who was diagnosed with severe dyslexia, moderate dyscalculia, ADHD and low IQ (low 80s). People who had evaluated her said that they had never seen dyslexia as severe as this before. Her parents had been told by more than one professional that Maddie would probably never read... Continue Reading
Kimberly, US Edublox Online Tutor May 23, 2019
“His ability to decipher words is phenomenal”
Kenny’s ability to spell now is stunning all of us. His ability to decipher words is phenomenal.... Kenny has learned that reading can be enjoyed and how to enjoy it... He is reading now on an above grade level average and scored above grade level on his State tests. Continue Reading
Donna, USA Edublox Online Tutor November 15, 2018